Sepsis screen
Lactate elevation + WBC + procalcitonin + HR trajectory mapped to Sepsis-3 criteria.
Decision support. ChironAI surfaces lab patterns to the ordering clinician for review. The clinician evaluates, orders any reflex testing, and signs the chart. ChironAI does not make a regulatory clearance claim; see Disclosures.
ChironAI CDSLabs
Lab patterns, not lab values.
A single lab value out of range is data. A trajectory across the patient’s longitudinal history is a pattern. ChironAI surfaces those patterns to the clinician who ordered the panel \u2014 ten canonical clinical patterns recognized end to end, with reference-range adjustment for demographic context. The clinician decides what to do with each.
Ten patterns
What ChironAI surfaces when the panel comes back.
AKI (acute kidney injury)
Creatinine and BUN trajectory + urine output (where available) mapped to KDIGO staging.
Thyroid panel
TSH + free T4 + (free T3) trajectory recognized as subclinical hypo/hyper, overt, or sick-euthyroid.
Lipid panel
LDL, HDL, triglycerides, non-HDL cholesterol mapped to ASCVD risk stratification.
Diabetic series
A1c + fasting glucose + (random) trajectory mapped to ADA Standards of Care 2026.
Hepatic panel
AST, ALT, GGT, alkaline phosphatase, bilirubin, INR trajectory mapped to NAFLD, viral, drug-induced, obstructive patterns.
Renal panel
eGFR, creatinine, BUN, electrolytes, UACR trajectory mapped to chronic-kidney-disease staging.
Infectious panel
WBC + differential + culture results mapped to common infectious-disease patterns.
Oncology panel
Tumor markers (CA-125, PSA, CEA, CA 19-9, AFP) trajectory mapped to treatment response or recurrence.
Cardiovascular panel
Troponin, BNP/NT-proBNP, D-dimer trajectory mapped to ACS, heart-failure, and PE risk frameworks.
Two examples in the product
ChironAI™ CDSThyroid function panel
Must review before final
Decision-support output. Clinician review and attestation required before this content is signed into the chart.
Pattern recognized — Subclinical hypothyroidism progressing
TSH trending upward over the last 14 months (3.2 → 4.8 → 5.9 → 7.1 mIU/L). Free T4 remains in normal range. Pattern consistent with subclinical hypothyroidism with increasing biochemical severity.
Repeat TSH + free T4 in 4–6 weeks. Discuss patient symptoms; if symptomatic or TSH > 10 mIU/L, consider levothyroxine initiation.
TSH (mIU/L) — last 14 months
7.1
pattern match
ChironAI™ CDSSepsis screening panel
Must review before final
Decision-support output. Clinician review and attestation required before this content is signed into the chart.
Pattern recognized — Early sepsis screen positive
WBC 14.2 (elevated). Lactate 2.6 mmol/L (elevated above 2.0 threshold). Procalcitonin 0.9 ng/mL (intermediate). HR 112 sustained. Pattern meets two of three Sepsis-3 SOFA criteria with elevated lactate.
Initiate sepsis bundle within 60 minutes. Blood cultures ×2 before antibiotics. Empirical broad-spectrum antibiotics per institutional protocol. Crystalloid 30 mL/kg if MAP < 65.
Lactate (mmol/L) — last 8 hours
2.6
pattern match
Reference-range adjustment
The system does not flag pediatric values as adult abnormal.
Reference ranges shift across demographic context \u2014 age, sex, pregnancy status, specialty context. A creatinine of 0.4 mg/dL is normal for a 3-year-old and would falsely trigger an AKI alert if compared to adult reference ranges.
ChironAI’s labs posture adjusts reference ranges for the demographic context before pattern recognition runs. Pediatric, geriatric, pregnancy, and specialty- specific reference ranges live in the same vocabulary the lab itself uses, and the system matches them.
A note to the reader